Associate Engineer, Immunoassay System Integration

Spear Bio, founded in 2021, is a well-funded and rapidly growing start-up headquartered in Woburn, Massachusetts. Our proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), is a novel wash-free immunoassay platform, offering unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring by providing scalable, ultrasensitive solutions that deliver unparalleled accuracy in measuring low-abundant biomarkers, enabling clinicians and researchers to improve patient outcomes and advance global health.

Spear Bio is seeking a hands-on and motivated Associate Engineer, System Integration to support the development and integration of robotics, liquid handling instruments, software, and assay workflows within our next-generation ultrasensitive immunoassay platform. You will work closely with cross-functional teams helping to assemble, test, and refine complex systems. This is an exciting opportunity to gain broad, system-level experience while contributing to the advancement of a transformative life sciences platform.

Responsibilities

• Assist with the integration of hardware, software, and reagent components into a cohesive immunoassay platform, ensuring functional alignment across subsystems.
• Collaborate with internal teams and external partners to troubleshoot technical issues related to subsystems, consumables, and instrumentation (e.g., liquid handlers, sensors, and robotics).
• Execute system integration and verification test protocols; document results and support the development of technical reports and design documentation.
• Identify and address system-level issues; contribute to continuous improvement initiatives for workflow robustness and operational efficiency.
• Maintain organized records of system configurations, integration workflows, and experimental outcomes.
• Support calibration, maintenance, and review of system performance for development and pilot-scale platforms.
• Contribute to root cause investigations and system refinements to enhance usability, scalability, and reliability.
  
  

Requirements

• 1–2 years of experience with lab systems integration, lab instrumentation, or diagnostics platforms (will consider relevant internships/co-ops in the above areas) required.
• Bachelor’s or Master’s degree in Bioengineering or a related discipline.
• Strong hands-on skills in assembling mechanical or fluidic components and troubleshooting systems.
• Familiarity with diagnostic laboratory instruments and life science automation systems required.
• Prior experience using liquid handling systems (e.g., Hamilton, Tecan, Formulatrix).
• Working knowledge of CAD tools (e.g., SolidWorks) and data analysis software (e.g., Excel, MATLAB, Python).
• Understanding of system verification and regulatory design controls (e.g., ISO 13485, FDA QSR) is a plus.
• Detail-oriented, with strong organizational and documentation skills.
• Effective communicator and team player, able to collaborate in a fast-paced, interdisciplinary environment.
  
  

We offer competitive compensation, meaningful stock ownership, comprehensive benefits, and a great work environment. This is an opportunity to enter an innovative, high-growth startup at an early stage. We are focused on identifying candidates who have demonstrated leadership and excellence throughout their careers and are excited by the prospect of building an industry-leading company.

Spear Bio Inc. provides equal opportunity in employment to all persons. No person shall be denied equal access because of race, creed, color, religion, national origin, sex, sexual orientation, gender identity, age, or physical/mental disability.

Spear Bio does not accept blind resume submissions from external recruiting agencies. Any unsolicited resumes or candidate information submitted without prior written agreement will be deemed the property of Spear Bio, and no placement fees will be paid.