Senior Scientist, in vivo Pharmacology

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company's approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking a highly motivated and collaborative Senior Scientist to join our in vivo Pharmacology team. This individual will lead a sub-team within the in vivo Pharmacology group, manage daily operations at a vivarium site and manage, lead, and perform in vivo studies in murine oncology models to develop our genetic medicines using engineered recombinases with non-viral delivery. Reporting to the Associate Director of in vivo Pharmacology and working closely with cross-functional teams, this is a unique opportunity to work on the front lines of innovation and contribute to the advancement of transformational therapies.

Key Responsibilities & Accountabilities:

• Design, plan and execute all aspects of in vivo mouse studies, including tumor models, to support platform and therapeutic development
• Evaluate recombinase-based gene editing technologies and transcriptional effectors in animal models, including administration, in-life analysis (e.g., imaging, cytokine analysis), and post-mortem tissue processing
• Generate and manage study documentation, including SOPs, IACUC protocols and study reports
• Analyze, interpret and effectively communicate experimental data and findings to inform project direction and decision-making
• Manage a small team, focusing on in vivo mouse handling
• Collaborate with internal multidisciplinary teams and external partners to ensure seamless execution and progression of in vivo research programs
• Maintain detailed and accurate laboratory records in compliance with data integrity and documentation standards, including collaborating with regulatory and preclinical teams to ensure robust documentation of non-clinical findings for submissions
• Draft non-clinical study reports and contribute to the preparation of regulatory documents, including IND-enabling packages
  
  

Qualifications & Skills:

• Ph.D. in Pharmacology, Immunology, Immuno-oncology, or a related field with 4-6 years of relevant experience, or a Master's degree with 10+ years of experience
• Hands-on expertise in in vivo pharmacology, including mouse handling, surgical procedures, IV tail vein injection, body weight monitoring, blood collection, tumor model development and tumor growth analysis, tissue dissociation and processing
• Experience with thawing and dosing of T cells, PBMCs or other immune cell types into mice
• Experience with LNP or CART delivery technologies and genetic medicine platforms
• Demonstrated ability to design, execute, interpret, and troubleshoot in vivo studies and to coordinate activities of multiple study contributors, including integrating information from multiple sources into study design
• Experience coordinating with animal vendors, CROs or external collaborators
• Familiarity with T cell or PBMC isolation and handling from peripheral blood and downstream immunological or molecular assays
• Experience with ex vivo analytical techniques, such as flow cytometry, cytokine analysis and ddPCR, preferred
• Proven experience in managing highly effective teams or individuals
• Demonstrated ability to work independently in a laboratory setting, learn new techniques, multitask effectively, and maintain meticulous records, including documenting and maintaining an organized lab notebook, lab inventory and experimental results
• Excellent organization and communication skills, with a team-first mindset and the ability to convey technical information
• Analytical thinker with the ability to distill complex data into clear, actionable insights