Associate Scientist / Sr Associate Scientist - in vivo Pharmacology
Sonoma Biotherapeutics, Inc.
Date: 4 hours ago
City: South San Francisco, California
Contract type: Full time
About Sonoma Biotherapeutics
Sonoma Biotherapeutics is a South San Francisco- and Seattle-based clinical-stage biotechnology company developing engineered regulatory T cell (Treg) therapies to treat serious autoimmune and inflammatory diseases by restoring balance to the immune system. Founded by pioneers in Treg biology and cell therapy, the company brings together leading expertise and proprietary methodologies for the discovery and development of disease modifying and curative therapies. Sonoma Bio has initiated two Phase 1 studies to evaluate the safety and proof-of-mechanism of the company’s lead Treg cell therapy candidate, SBT-77-7101, in patients with rheumatoid arthritis and hidradenitis suppurativa. The company has a partnership with Regeneron to discover, develop and commercialize novel regulatory T cell therapies. More information at www.sonomabio.com.
Position Summary
We are seeking a hardworking, enthusiastic Associate Scientist / Senior Associate Scientist to support the In Vivo Pharmacology group and help build the best-in-class regulatory T cell (Treg) therapies for autoimmune diseases. The ideal candidate will have experience conducting in vivo studies in mouse models of autoimmunity, inflammatory diseases and/or cancer. Proficiency working with mice is required. The successful candidate will demonstrate the ability to carry out studies independently and in cross-functional teamwork settings, demonstrate creativity and apply critical thinking, help develop new pharmacology models and protocols, and generate reproducible, high-quality data to inform and support the development of Sonoma Biotherapeutics’ next generation CAR-T cell therapy programs.
Roles And Responsibilities
The day-to-day life of a team member of the In Vivo Pharmacology Team involves executing in vivo studies for pipeline programs and discovery projects. As a member of the IVP team, you will have the opportunity to contribute to mouse model development to build novel, reliable, and reproducible disease-relevant models that will be essential to make critical decisions to support and advance pipeline programs. You will be a critical team member working on IND-enabling studies, and directly contributing to move SonomaBio’s drug candidates into the clinic.
Sonoma Biotherapeutics is an Equal Opportunity Employer
At Sonoma Biotherapeutics, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.
Sonoma Biotherapeutics is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply. Please submit your resume along with a cover letter to [email protected]. Resumes may also be submitted without applying for a specific job.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at [email protected].
Sonoma Biotherapeutics is a South San Francisco- and Seattle-based clinical-stage biotechnology company developing engineered regulatory T cell (Treg) therapies to treat serious autoimmune and inflammatory diseases by restoring balance to the immune system. Founded by pioneers in Treg biology and cell therapy, the company brings together leading expertise and proprietary methodologies for the discovery and development of disease modifying and curative therapies. Sonoma Bio has initiated two Phase 1 studies to evaluate the safety and proof-of-mechanism of the company’s lead Treg cell therapy candidate, SBT-77-7101, in patients with rheumatoid arthritis and hidradenitis suppurativa. The company has a partnership with Regeneron to discover, develop and commercialize novel regulatory T cell therapies. More information at www.sonomabio.com.
Position Summary
We are seeking a hardworking, enthusiastic Associate Scientist / Senior Associate Scientist to support the In Vivo Pharmacology group and help build the best-in-class regulatory T cell (Treg) therapies for autoimmune diseases. The ideal candidate will have experience conducting in vivo studies in mouse models of autoimmunity, inflammatory diseases and/or cancer. Proficiency working with mice is required. The successful candidate will demonstrate the ability to carry out studies independently and in cross-functional teamwork settings, demonstrate creativity and apply critical thinking, help develop new pharmacology models and protocols, and generate reproducible, high-quality data to inform and support the development of Sonoma Biotherapeutics’ next generation CAR-T cell therapy programs.
Roles And Responsibilities
- Conduct in vivo experiments to assess functionality of engineered Treg candidates
- Conduct in vitro/ex vivo experiments to analyze cells ex vivo by flow cytometry, ELISA, IHC etc.
- Organize and manage daily operations in the vivarium
- Collaborate with team leaders, scientists, and peers to design, execute, and troubleshoot studies
- Must be highly organized, and execute diligent and detailed documentation of experimental procedures
- Generate, analyze, interpret, and present data to project teams and research staff
- Bachelor’s or Master’s degree in life sciences, in immunology, cell biology or a related field.
- 3+ years (Associate Scientist) or 5+ years (Senior Associate Scientist) of relevant hands-on in vivo experience
- Proficiency in flow cytometric analysis is strongly preferred
- Strong scientific understanding and logical thinking are required
- Excellent verbal and written communication skills, with the ability to analyze and present data and write reports efficiently and effectively
- Proficiency in data analysis using Prism, Excel and flow cytometry analysis software
- Comfortable in a rapid-moving team and highly productive and collaborative team environment
- Experience with syngeneic and xenogeneic pharmacology models
- Highly proficient in mouse handling and injections / administration (ip, iv, sc, pr, po)
- Isolation of cells from murine tissues for phenotypic and functional analysis
- Experience in in vitro and ex vivo techniques (e.g, Multi-color flow cytometry, ELISA)
- Experience with primary cell isolation and culture
- Dedicated to maintaining high laboratory standards regarding safety and quality
- Must be able to understand, conduct, and interpret results of technically challenging experiments with minimal supervision
The day-to-day life of a team member of the In Vivo Pharmacology Team involves executing in vivo studies for pipeline programs and discovery projects. As a member of the IVP team, you will have the opportunity to contribute to mouse model development to build novel, reliable, and reproducible disease-relevant models that will be essential to make critical decisions to support and advance pipeline programs. You will be a critical team member working on IND-enabling studies, and directly contributing to move SonomaBio’s drug candidates into the clinic.
Sonoma Biotherapeutics is an Equal Opportunity Employer
At Sonoma Biotherapeutics, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.
Sonoma Biotherapeutics is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply. Please submit your resume along with a cover letter to [email protected]. Resumes may also be submitted without applying for a specific job.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at [email protected].
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